Em borderlands\WillowGame\Config, abra o arquivo DefaultEngine.ini e procure por essas linhas:
[FullScreenMovie]
StartupMovies=2K_logo
StartupMovies=Gearbox_logo
StartupMovies=NVidia
StartupMovies=Loading
SkippableMovies=2K_logo
SkippableMovies=Gearbox_logo
SkippableMovies=Attract
SkippableMovies=NVidia
Adicione ";" antes de StartupMovies em cada linha, dessa forma:
;StartupMovies=2K_logo
;StartupMovies=Gearbox_logo
;StartupMovies=NVidia
;StartupMovies=Loading
SkippableMovies=2K_logo
SkippableMovies=Gearbox_logo
SkippableMovies=Attract
SkippableMovies=NVidia
Salve o arquivo e inicie o jogo.